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An Introduction to Medicinal Chemistry

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An Introduction to Medicinal Chemistry

ISBN13:9780198866664

出版社:Oxford Univ Pr

作者:Graham L. Patrick

裝訂:平裝

規格:27.5cm*22.1cm*3.8cm (高/寬/厚)

版次:7

出版日:2023/06/15

定價:2390

【內容】

Description

The market-leader in medicinal chemistry: clear, supportive, and practical. It helps students to effortlessly make the link from theory to real-life applications using practical and focused coverage alongside a package of supportive online resources.

  • The author's renowned clarity of writing and the book's logical structure help to address the challenges of teaching and studying Medicinal Chemistry.

  • New chapters on Protein Kinase and Antibodies provide insightful, up-to-date coverage of some of the most significant topics in the subject today

  • The pedagogical features enhance student engagement, which supports better knowledge retention, and a more confident application of concepts and ideas to unfamiliar problems.

  • Boxes and case studies support a real-life applied approach that helps lecturers to show how theoretical content relates to the practical reality of medicinal chemistry.

  • Full-colour images throughout the new edition enhance the student experience by helping them to better visualise the concepts presented.

  • New and updated exercises, questions, and activities throughout the book and online help students to hone their problem-solving skills.

  • Also available as an e-book with functionality, navigation features, and links that offer extra learning support.

New to this edition

  • Newly added high-level Multiple-Choice Questions to support self-directed learning and challenge the understanding of the processes and concepts covered

  • Updated and new Protein Data Bank Exercises available online.

  • New and updated assignments to help students develop their data analysis and problem-solving skills

  • Full-colour images throughout the new edition enhance the student experience by helping them to better visualise the concepts presented.

  • Also available as an e-book with functionality, navigation features, and links that offer extra learning support.


Table of Contents

  • 1:Drugs and Drug Targets

  • 2:Protein Structure and Function

  • 3:Enzymes: Structure and Function

  • 4:Receptors: Structure and Function

  • 5:Receptors and Signal Transduction

  • 6:Nucleic Acids: Structure and Function

  • 7:Enzymes as Drug Targets

  • 8:Receptors as Drug Targets

  • 9:Nucleic Acids as Drug Targets

  • 10:Miscellaneous Drug Targets

  • 11:Pharmacokinetics and Related Topics

  • Case Study 1:Statins

  • 12:Drug Discovery: Finding a Lead

  • 13:Drug Design: Optimizing Target Interactions

  • 14:Drug Design: Optimizing Access to the Target

  • 15:Getting the Drug to Market

  • Case Study 2:The Design of ACE Inhibitors

  • Case Study 3:Artemisinin and Related Antimalarial Drugs

  • Case Study 4:The Design of Oxamni

  • Case Study 5:Fosfidomycin as an Antimalarial Agent

  • 16:Combinatorial and Parallel Synthesis

  • 17:In Silico Drug Design

  • 18:Quantitative Structure-Activity Relationships

  • Case Study 6: De Novo Design of a Thymidylate Synthase Inhibitor

  • 19:Antibacterial Agents

  • 20:Antiviral Agents

  • 21:Anticancer Agents

  • 22:Protein Kinase Inhibitors as Anticancer Agents

  • 23:Antibodies and Other Biologics

  • 24:Cholinergics, Anticholinergics, and Anticholinestarases

  • 25:Drugs Acting on the Adrenergic Nervous System

  • 26:The Opioid Analgesics

  • 27:Anti-Ulcer Agents

  • 28:Cardiovascular Drugs

  • Case Study 7:Steroidal Anti-Inflammatory Agents

  • Case Study 8:Design of a Novel Antidepressant

  • Case Study 9:The Design and Development Of Aliskiren

  • Case Study 10:Factor Xa Inhibitors

  • Case Study 11:Reversible Inhibitors of HCV NS-34A Protease


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