An Introduction to Medicinal Chemistry
ISBN13:9780198866664
出版社:Oxford Univ Pr
作者:Graham L. Patrick
裝訂:平裝
規格:27.5cm*22.1cm*3.8cm (高/寬/厚)
版次:7
出版日:2023/06/15
定價:2390
【內容】
Description
The market-leader in medicinal chemistry: clear, supportive, and practical. It helps students to effortlessly make the link from theory to real-life applications using practical and focused coverage alongside a package of supportive online resources.
The author's renowned clarity of writing and the book's logical structure help to address the challenges of teaching and studying Medicinal Chemistry.
New chapters on Protein Kinase and Antibodies provide insightful, up-to-date coverage of some of the most significant topics in the subject today
The pedagogical features enhance student engagement, which supports better knowledge retention, and a more confident application of concepts and ideas to unfamiliar problems.
Boxes and case studies support a real-life applied approach that helps lecturers to show how theoretical content relates to the practical reality of medicinal chemistry.
Full-colour images throughout the new edition enhance the student experience by helping them to better visualise the concepts presented.
New and updated exercises, questions, and activities throughout the book and online help students to hone their problem-solving skills.
Also available as an e-book with functionality, navigation features, and links that offer extra learning support.
New to this edition
Newly added high-level Multiple-Choice Questions to support self-directed learning and challenge the understanding of the processes and concepts covered
Updated and new Protein Data Bank Exercises available online.
New and updated assignments to help students develop their data analysis and problem-solving skills
Full-colour images throughout the new edition enhance the student experience by helping them to better visualise the concepts presented.
Also available as an e-book with functionality, navigation features, and links that offer extra learning support.
Table of Contents
1:Drugs and Drug Targets
2:Protein Structure and Function
3:Enzymes: Structure and Function
4:Receptors: Structure and Function
5:Receptors and Signal Transduction
6:Nucleic Acids: Structure and Function
7:Enzymes as Drug Targets
8:Receptors as Drug Targets
9:Nucleic Acids as Drug Targets
10:Miscellaneous Drug Targets
11:Pharmacokinetics and Related Topics
Case Study 1:Statins
12:Drug Discovery: Finding a Lead
13:Drug Design: Optimizing Target Interactions
14:Drug Design: Optimizing Access to the Target
15:Getting the Drug to Market
Case Study 2:The Design of ACE Inhibitors
Case Study 3:Artemisinin and Related Antimalarial Drugs
Case Study 4:The Design of Oxamni
Case Study 5:Fosfidomycin as an Antimalarial Agent
16:Combinatorial and Parallel Synthesis
17:In Silico Drug Design
18:Quantitative Structure-Activity Relationships
Case Study 6: De Novo Design of a Thymidylate Synthase Inhibitor
19:Antibacterial Agents
20:Antiviral Agents
21:Anticancer Agents
22:Protein Kinase Inhibitors as Anticancer Agents
23:Antibodies and Other Biologics
24:Cholinergics, Anticholinergics, and Anticholinestarases
25:Drugs Acting on the Adrenergic Nervous System
26:The Opioid Analgesics
27:Anti-Ulcer Agents
28:Cardiovascular Drugs
Case Study 7:Steroidal Anti-Inflammatory Agents
Case Study 8:Design of a Novel Antidepressant
Case Study 9:The Design and Development Of Aliskiren
Case Study 10:Factor Xa Inhibitors
Case Study 11:Reversible Inhibitors of HCV NS-34A Protease
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